Julie C. Lively
Assistant Professor of Biology
B.A., Wellesley College; Ph.D., Massachusetts Institute of Technology
Campus Office
Spencer Hall 156
Telephone
(931) 598-1747
Email
jlively@sewanee.edu
RESEARCH & SCHOLARSHIP
My lab studies tumor development including the role of the tumor microenvironment in growth and metastasis.
We focus primarily on the roles of integrins, cell surface adhesion proteins, in various steps of tumor progression.
Alpha v integrins are of particular interest both for their role in angiogenesis, particularly endothelial cell function, as well as in the activation of TGF-beta in the tumor microenvironment.
Questions we are currently exploring in the context of integrin function:
- What regulates the formation of new blood vessels?
- What role does the vasculature play in metastasis?
- How do tumor cells interact with the endothelium?
- What role do immune cells play in metastasis?
- How do tumor cells interact with immune cells?
Students currently doing work in the laboratory are Jennifer Caldwell C’11, Sara Hildebrand C’11, Jaime de la Fuente C’12 and Luca Koritsanszky C’12
SELECTED PUBLICATIONS
Reynolds, A.R., Reynolds, L.E., Nagel, T.E., Lively, J.C., Robinson, S.D., Hicklin, D.J., Bodary, S., Hodivala-Dilke, K. (2004) Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice, Cancer Research, 64, 8643.
Yang, C., Zeisberg, M., Lively, J.C., Nyberg, P., Afdhal, N. and Kalluri, R. (2003) Integrin α1β1 and α2β1 are the Key Regulators of Hepatocarcinoma Cell Invasion Across the Fibrotic Matrix Microenvironment, Cancer Research, 63, 8312.
Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R. (2003) Tumstatin is an Endogenous Suppressor of Tumor Angiogenesis and Growth, Dependent on MMP-9 and αVβ3 Integrin, Cancer Cell, 3, 589.
Sudhakar, A., Sugimoto, H., Yang, C., Lively, J., Zeisberg, M., Kalluri, R. (2003) Human Tumstatin and Human Endostatin Exhibit Distinct Anti-angiogenic Activities Mediated by αVβ3 and α5β1 Integrins, PNAS USA, 100, 4766.
Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Francis, S.E., Hodivala-Dilke, K., Xiao, Q. (2002) The Diverse Roles of Integrins and Their Ligands in Angiogenesis, Cold Spring Harbor Symposium Quantitative Biology, 67, 143.
Maeshima, Y.1, Sudhakar, A.1, Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002) Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis, Science, 295, 140.
Reynolds, L.E.1, Wyder, L.1, Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D., Hynes, R.O. and Hodivala-Dilke, K.M. (2002) Enhanced Pathological Angiogenesis in mice lacking β3 Integrin and β3 / β5 Integrins, Nature Medicine, 8, 27.
OTHER PROJECTS
I have a great interest in active learning and alternative pedagogy. I maintain an active role in a group developing POGIL based activities for Biology and Biochemistry.
USEFUL LINKS
